Physiology 735. Auditory Neuroscience.

1hr. 15min. lectures. TTh.

Friday labs.

 

Lec 1. Introduction to Hearing.

Lec 2. Properties of the outer ear and the middle ear.

Lec 3. Structure of the cochlea.

Lec 4. Cochlear mechanics.

Lec 5. Physiology of hair cells.

Lec 6. Otoacoustic emmissions.

Lec 7. Auditory nerve anatomy & physiology.

Lec 8. Two-tone suppression. Acoustic trauma.

Lec 9. Two-tone distortion. Coding of amplitude modulated signals.

Lec 10. Pitch, two-tone distortion and two-tone suppression.

Lec 11. Encoding speech in the auditory nerve.

Lec 12. Temporal coding in the auditory nerve, masking, efferents.

Lec 13. The olivocochlear efferent system. Neural and mechanical measures.

Lec 14. Cochlear prosthesis.

Midterm.

 

Lec 15. Anatomy of the cochlear nuclear complex.

Lec 16. Physiology of the VCN.

Lec 17. Physiology of the DCN.

Lec 18. The processing of Complex signals in the cochlear nucleus.

Lec 19. Neurotransmitters in the cochlear nucleus.

Lec 20. Anatomy and physiology of the superior olive complex.

Lec 21. Physiology of the superior olivary complex.

Lec 22. Anatomy of the inferior and superior colliculi.

Lec 23. Physiology of the inferior collicus.

Lec 24. Spatial mapping in the auditory system.

Lec 25. Anatomy of the medial geniculate body.

Lec 26. Anatomy of the cortex.

Lec 27. Physiology of the auditory cortex.

Lec 28 . Processing speech and other complex signals in the auditory cortex.

Lec 29. Processing binaural sounds in the auditory cortex. Plasticity of the cortex.

 

Final Exam

 

 

 

 


 

 

LAB exercises.

 

Lab 1. Use of MATLAB of a PC for exploring nonlinear signal processing.

 

Lab 2. Use of MATLAB. Spectral analysis and filtering applied to vocalizations.

 

Lab 3. An interlude with pitch.

 

Lab 4. Analyze previously recorded responses of an auditory nerve fiber to a standard set of stimuli to become familiar with single-unit analysis techniques.

 

Lab 5. Recording Gross potentials. The goal is to become familiar with some of the techniques of recording gross potentials in the auditory system. This involves the use of relatively large electrodes, usually made out of silver wire. The potentials are the expression of a population of neurons and/or a bundle of nerve fibers.

 

Lab 6. Electrophysiological recording from single auditory nerve fibers. The goal is to have each individual locate a nerve fiber and collect an FTC, response area, short tone at CF, rate curve (with and without randomization). There will be Macros that perform the necessary initialization of the equipment. The animal will be prepared and the electrode positioned above the auditory nerve.

 

Lab 7. Electrophysiological recording from single neurons in the cochlear nucleus. The goal is to have each individual locate a cochlear nucleus unit and collect an FTC, response area, short tone at CF, rate curve (with and without randomization). There will be 'Macros' that perform the necessary initialization of the equipment. The animal will be prepared and the electrode positioned above the cochlear nucleus.