Our laboratory is interested in understanding the neural basis of higher order processes or cognition. Because the execution of voluntary actions usually involves processes such as target selection, learning, memory, planning and expectation, motor systems are well suited to serve as model systems in which to study these processes. Therefore, we investigate neural processes leading up to the execution of movements of the eyes, in particular, those eye movements that lead to rapid changes in the line of sight - saccades.

We have a multi-technique approach to the study of these processes. First, we record electrical activity of single neurons while the subjects perform eye movement tasks designed to tap into cognitive processes. Second, we activate or inactivate particular regions of the brain to produce behaviors or interfere with ongoing behaviors and neural processing. Finally, because damage to certain brain regions produces profound clinical disorders such as Parkinson's disease and Huntington's disease, we study eye movements of both healthy and diseased human subjects to further our understanding of the role these structures play in both cognition and in producing the debilitating effects of these disorders.

Recent Publications

1. Li, X. and Basso, M.A. (2008) Preparing to move increases the sensitivity of superior colliculus neurons. J. Neurosci., 28(17):4561-77
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2. Kim, B. and Basso, M.A. (2008) Saccade target selection in the superior colliculus: a signal detection theory approach. J. Neurosci., 28(12):2991-3007
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3. Wark, H.A., Garell, P.C., Walker. A.L. and Basso, M.A. (2008) A case report on fixation instability in Parkinson's disease with bilateral deep brain stimulation implants. J Neurol Neurosurg Psychiatry., 79(4):443-7
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(This page last modified on Aug. 14, 2009)