Hector Valdivia

Professor
M.D., 1982, Ph.D., 1987, National University of Mexico

Contact Information
Email: valdivia@physiology.wisc.edu
(608) 265-5960 Phone
(608) 265-5512 Fax

Research Interests
Molecular mechanisms underlying Ca²⁺ homeostasis of cardiac and skeletal muscle cells

Visit the Valdivia Lab

Purified sarcolemma and sarcoplasmic reticulum are fused to planar lipid bilayers to study the pharmacological regulation of Ca²⁺ channels and their kinetics of activation by laser flash photolysis of caged compounds; measurement of Ca²⁺ currents and intracellular Ca²⁺ levels in vivo using the patch-clamp technique in cells loaded with fluorescent Ca²⁺ indicators.

Research includes excitation-contraction coupling, intracellular Ca²⁺ signaling, and mechanisms of operation of ligand-gated Ca²⁺ channels.

Selected Publications

• Lokuta, A.J., Meyers, M.B., Sander, P.R., Fishman, G.I. and Valdivia, H.H. (1997). Modulation of cardiac ryanodine receptors by sorcin. J . Biol. Chem. 272:25333-25338.
  Abstract | Full Text | PDF
   
• Xiao, R.-P., Valdivia, H.H., Bogdanov, K., Valdivia, C., Lakatta, E. and Cheng, H. (1997).Termination of Ca²⁺-induced Ca²⁺ release by the immunophilin FK506-binding protein. J. Physiol. (Lond.) 500:343-354.
  Abstract
   
• Gomez, A.M., Valdivia, H.H., Cheng, H., Lederer, M., Santana, L.F., Cannell, M.B., McCune, S.A., Altschuld, R.A. and Lederer, W.J. (1997). Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science (Wash.) 276:800-806.
  Abstract | Full Text | PDF
   
• Lokuta, A.J., Rogers, T.B., Lederer, W. J. and Valdivia, H.H. (1995). Modulation of cardiac ryanodine receptors by a phosphorylation/dephosphorylation mechanism. J. Physiol. (Lond.) 487(3):609-622.
  Abstract
   
• Valdivia, H.H., Kaplan, J.H., Graham Ellis-Davies and W. J. Lederer (1995). Rapid adaptation of cardiac ryanodine receptors: modulation by Mg²⁺ and phosphorylation. Science (Wash.) 267:1997-2000.

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