Czajkowski Lab Publications

• Sancar, F., Ericksen, S.S., Kucken, A.M., Teissere, J.A. and Czajkowski, C. (2007) Structural determinants for high affinity zolpidem binding to GABA-A receptors. Mol. Pharmacol 71: 38-46. Epub 2006 Sep 29.
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• Kloda, J. H. and Czajkowski, C. (2007) Agonist-, antagonist-, and benzodiazepine-induced structural changes in the a1Met113-Leu132 region of the GABA-A receptor. Mol. Pharmacol 71: 483-493. Epub 2006 Nov 15.
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• Muroi Y, Czajkowski C, Jackson MB. (2006) Local and Global Ligand-Induced Changes in the Structure of the GABA(A) Receptor Biochemistry Jun 13;45(23):7013-22. PMID: 16752892 [PubMed - in process]
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• Mercado J, Czajkowski C. (2006) Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation J Neurosci. Feb 15;26(7):2031-40. PMID: 16481436 [PubMed - indexed for MEDLINE]
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• Boileau AJ, Pearce RA, Czajkowski C. (2005) Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein. J Neurosci. Dec 7;25(49):11219-30. PMID: 16339017 [PubMed - indexed for MEDLINE]
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• Czajkowski C. (2005) Neurobiology: triggers for channel opening Nature. Nov 10;438(7065):167-8. No abstract available. PMID: 16281019 [PubMed - indexed for MEDLINE]
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• Wagner, D.A., Czajkowski, C., and Jones, M.V. (2004) An arginine involved in GABA binding and unbinding but not gating of the GABA-A receptor J. Neurosci. 24: 2733-2741.
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• Sancar, F. and Czajkowski, C. (2004) A GABA-A receptor mutation linked to human epilepsy (g2 R43Q) impairs cell surface expression of abg receptors. J. Biol. Chem. 279: 47034-47039.
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• Newell, J. G., McDevitt, and Czajkowski, C. (2004) Mutation of glutamate 155 of the GABA-A receptor b2 subunit produces a spontaneously open channel: A trigger for channel activation. J. Neurosci. 24: 11226-11235.
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• Boileau, A.J., Li, T., Benkwitz, C, Czajkowski, C and Pearce, R.A. (2003) Effects of g2S Subunit Incorporation on GABA-A Receptor Macroscopic Kinetics. Neuropharmacology 44: 1003-1012.
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• Newell, J.G., Czajkowski, C., (2003). The GABAA receptor alpha1 subunit pro174-Asp191 segment is involved in GABA binding and channel gating. J Biol Chem.
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• Kucken, A.M., Teissere, J.A., Seffinga-Clark, J., Wagner, D.A., Czajkowski, C., (2003). Structural requirements for imidazobenzodiazepine binding to GABA(A) receptors. Mol Pharmacol. 63, 289-96.
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• Holden, J.H., Czajkowski, C., (2002). Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions. J Biol Chem. 277, 18785-92.
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• Bowser, D.N., Wagner, D.A., Czajkowski, C., Cromer, B.A., Parker, M.W., Wallace, R.H., Harkin, L.A., Mulley, J.C., Marini, C., Berkovic, S.F., Williams, D.A., Jones, M.V., Petrou, S., (2002). Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A. 99, 15170-5.
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• Boileau, A.J., Newell, J.G., Czajkowski, C., (2002). GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions. J Biol Chem. 277, 2931-7.
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• Boileau, A., Baur, R., Sharkey, L., Sigel, E., Czajkowski, C., (2002). The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes. Neuropharmacology. 43, 695-700.
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• Horenstein, J., Wagner, D. A., Czajkowski, C. & Akabas, M. H. (2001) Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment. Nat Neurosci 4(5); 477-485.
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• Teissere, J. A. & Czajkowski, C. (2001) A Beta-Strand in the Gamma2 Subunit Lines the Benzodiazepine Binding Site of the GABAA Receptor: Structural Rearrangements Detected during Channel Gating. J Neurosci 21(14): 4977-4986.
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• Wagner, D. A. & Czajkowski, C. (2001) Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation. J Neurosci 21(1): 67-74.
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• Kucken, A. M., Wagner, D. A., Ward, P. R., Teissere, J. A., Boileau, A. J. & Czajkowski, C. (2000) Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor. Mol Pharmacol 57(5): 932-939.
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• Li, X., Czajkowski, C. and Pearce, R. A. (2000) Rapid and direct modulation of GABAA receptors by halothane. Anethesiology 92: 1366-75.
   
• Boileau, A.J. and Czajkowski, C. (1999) Identification of Transduction Elements for Benzodiazepine Modulation of the GABA-A Receptor: Three Residues Are Required for Allosteric Coupling. J. Neurosci. 19: 10213-10220
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• Boileau, A.J., Evers, A. R., Davis, A. F. and Czajkowski, C. (1999) Mapping the agonist binding site of the GABAA receptor: Evidence for a beta-strand. J. Neurosci. 19: 4847-4854.
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• Connor, J. X., Boileau, A. J., Czajkowski, C. (1998) GABAA alpha1-EGFP fusion protein requires a beta subunit for functional surface expression. J. Biol. Chem. 273:28906-28911.
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• Boileau, A.J., Kucken, A.M., Evers, A.R. & Czajkowski, C. (1998) Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric GABAA receptor subunits. Mol. Pharmacol. 53:295-303.
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• Krasowski, M.D., O'Shea, S. M., Rick, C. E., Whiting, P.J., Hadingham, K. L., Czajkowski, C., and Harrison, N. L. (1997) Alpha subunit isoform influences GABAA receptor modulation by propofol. J. Neuropharmcol. 36(7): 941-949.

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