I.  Nanomechanics of Ca2+-triggered membrane fusion.

 

II.  Elucidation of the receptors, entry pathways, and the molecular basis for translocation across membranes, of Botulinum (BoNT) and Tetanus neurotoxins (TeNT). 

III.  How changes in the membrane fusion machinery underlie aspects of synaptic plasticity.

Chapman Laboratory -  2008

IV. Structure and function of fusion pores.

Jackson, MB. and Chapman, ER. Nat. Struct Mol. Biol. 2008, Jul 3; 15(n7):684-689http://www.ncbi.nlm.nih.gov/pubmed/18596819?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC. 2006. Dec 21; 444(7122):1096-100http://www.ncbi.nlm.nih.gov/pubmed/17167418?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Chapman, ER. Nat Rev mol Cell Biol. 2002. Jul;3(7):498-508http://www.ncbi.nlm.nih.gov/pubmed/12094216?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

  1. IV.Cellular Trafficking and Localization of Various Synaptotagmin isoforms.